Formulation and Evaluation of Lovastatin Solid Dispersions with Pregelatinised Starch as Newer Superdisintegrant
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چکیده
منابع مشابه
Formulation & Evaluation of Oral Disintegrating Tablets of Lamotrigine Solid Dispersions
Lamotrigine is used in the treatment of CNS disorders, particularly epilepsy; pain; oedema; multiple sclerosis and psychiatric indications including bipolar disorder. Lamotrigine belongs to biopharmaceutical classification systems, BCS class II (Low solubility & High permeability). In addition, it requires immediate therapeutic action hence the main objective of this study is to improve the sol...
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Carbamazepine is a water-insoluble antiepileptic drug. Being a BCS class-II drug, its absorption is dissolution rate limited. Solid dispersions were prepared to enhance the dissolution rate of the drug. Crospovidone and croscarmellose sodium were used as the hydrophilic carriers. Solid dispersions showed a remarkable enhancement in the dissolution rate of the drug. In the present research work,...
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In the present study, corn Starch-Neusilin UFL2 conjugates were prepared by physical, chemical, and microwave methods with the aim of using the conjugates as tablet superdisintegrant. Various powder tests, namely, angle of repose, bulk density, tapped density, Hausner's ratio, Carr's index, swelling index, and powder porosity were conducted on the samples. The conjugates were characterized by A...
متن کاملformulation & evaluation of oral disintegrating tablets of lamotrigine solid dispersions
lamotrigine is used in the treatment of cns disorders, particularly epilepsy; pain; oedema; multiple sclerosis and psychiatric indications including bipolar disorder. lamotrigine belongs to biopharmaceutical classification systems, bcs class ii (low solubility & high permeability). in addition, it requires immediate therapeutic action hence the main objective of this study is to improve the sol...
متن کاملMicrowave Assisted Synthesis and Evaluation of Cross-Linked Carboxymethylated Sago Starch as Superdisintegrant
The aim of this study was to modify the sago starch and evaluate its efficacy as tablet disintegrant. Cross-linked carboxymethylated sago starch (CMSS) was synthesized using native sago starch (SS) and monochloroacetic acid (MCA) with sodium hydroxide in microwave radiation environment. FT-IR analysis of the sample confirmed the carboxymethylation by showing absorption peak at 1607.2 cm. CMSS w...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Research
سال: 2012
ISSN: 2454-8405,0973-7200
DOI: 10.18579/jpcrkc/2012/11/2/79341